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This enables IgG auto-Abs to accumulate in the body at levels that allow efficient blocking of their physiological targets, which may interfere with their biological functions or lead to destruction of the target [14]

At 300 mcg, which is the standard current protocol, the effect size is likely more modest still

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Manna I, Quattrone A, De Benedittis S et al (2021) Exosomal miRNA as peripheral biomarkers in Parkinsons disease and progressive supranuclear palsy: a pilot study